A) Monoclonal antibody anti-CD40 was injected into Rag-/- mice to induce inflammation in the large intestine. The anti-inflammatory efficacy of antibody drug candidate anti-SF1 was tested.

B) Body weight of each mice was monitored and normalized to their initial weight.

C) Disease activity index of each mice was scored.

D) Representative microscopy images (10x) of isotype or anti-SF1 of mice colon section.